Anticonvulsant pregabalin linked to major birth defects
The commonly prescribed medicine, pregabalin (marketed in Australia as Lyrica), has been linked to major birth defects, a new study reveals.
Women who take the drug in the first trimester of pregnancy are 3 times more likely to have a baby with malformations than those not on the medication.
Heart defects and structural problems with the central nervous system (CNS) or other organs are the most common adverse fetal effects associated with the drug which is primarily used to treat neuropathic pain, fibromyalgia and epilepsy.
The findings highlight the need for caution when women of childbearing age are taking pregabalin.
The study of 164 women who took pregabalin during pregnancy and 656 pregnant women who were not taking any anticonvulsant medication, found women on pregabalin were 6 times more likely to have a pregnancy with a major defect in the central nervous system.
The literature also shows relatively low levels of exposure to the drug may be enough to cause fetal malformations. In this study pregabalin was discontinued at around 6 weeks suggesting many of these pregnancies were unplanned.
However, the Swiss researchers say they can’t draw any definitive conclusions from their work as most of the women on pregabalin were also taking other medications at the time.
‘The study was small and the results need to be confirmed with larger studies, but these results do signal that there may be an increased risk for major birth defects after taking pregabalin during the first trimester of pregnancy,” says lead author Dr Ursula Winterfeld, from Lausanne University Hospital.
A spokesperson from Pfizer, which markets pregabalin under the brand name, Lyrica, says it should also be noted that the women taking the drug also had higher rates of smoking and diabetes “all of which negatively affect pregnancy outcomes”.
Here is the Australian Consumer Medicine Information for Lyrica.
The local Australian product information states: Lyrica has not been studied in pregnant women and Lyrica should not be used during pregnancy unless the benefit to the mother clearly outweighs the potential risk to the fetus.
19 May 2016
Last Reviewed: 19/05/2016
Reproduced with kind permission from 6minutes.com.au.
Pregnancy outcome following maternal exposure to pregabalin may call for concern www.neurology.org/content/early/2016/05/18/WNL.0000000000002767.short
Fetal alcohol spectrum disorder
Drinking alcohol while pregnant or breast feeding can harm your baby. Find out about the features of fetal alcohol spectrum disorder and how to prevent it.
Whether you are thinking about having a baby for the first time or have been pregnant before, with a little planning you can give yourself the best chance of a healthy pregnancy and baby.
Diabetes and getting pregnant
Your questions answered about how to ensure you have a safe pregnancy if you have diabetes.
Congenital heart defects
Congenital heart defects are problems with the structure of the heart that are present from birth. The defects develop during pregnancy. In Australia, as many as one baby in 100 is born with a heart defect.
Epilepsy is a condition in which the electrical and chemical activity of the brain loses its usual co-ordination for short periods of time, resulting in seizures (also called fits or convulsions).