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Consumer Medicine Information
This leaflet answers some common questions about Tryzan.
It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.
All medicines have benefits and risks. Your doctor has weighed the risks of you taking Tryzan against the benefits expected for you.
If you have any concerns about taking this medicine, talk to your doctor or pharmacist.
Keep this leaflet with your medicine. You may need to read it again.
Tryzan belongs to a group of medicines called angiotensin converting enzyme (ACE) inhibitors.
Tryzan is used to treat:
Tryzan is also used to reduce the risk of cardiovascular problems and complications in patients aged 55 years or more with heart or blood vessel disease, or diabetes.
Tryzan is used to lower high blood pressure (hypertension). Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day and can be influenced by how busy or worried you are. You have hypertension when your blood pressure stays higher than is needed, even when you are calm and relaxed.
There are usually no symptoms of hypertension. The only way of knowing that you have hypertension is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems, including stroke, heart disease and kidney failure.
Heart Failure after a Heart Attack
Tryzan may be used after a heart attack. A heart attack occurs when one of the major blood vessels supplying blood to your heart becomes blocked. This means that your heart muscle cannot receive the oxygen it needs and becomes damaged. This may lead to further problems, such as heart failure, irregular heart rhythms and blood clots.
Heart failure means that the heart muscle is weak and cannot pump blood strongly enough to supply all the blood needed throughout the body. Heart failure is not the same as heart attack and does not mean that the heart stops. Heart failure may start off with no symptoms, but as the condition progresses, patients may feel short of breath or may get tired easily after light physical activity such as walking. Some patients may wake up short of breath at night.
Fluid may collect in different parts of the body, often first noticed as swollen ankles and feet.
Tryzan may be used to treat some kidney problems. Some conditions such as diabetes and hypertension can lead to kidney problems. These problems develop slowly over several years. Good control of your blood sugar and blood pressure are important in keeping your kidneys healthy, but may not always prevent kidney damage from occurring.
Prevention of Cardiovascular Problems and Complications
Tryzan may be used to reduce the risk of some of the problems and complications that may arise in patients aged 55 or more who have problems such as coronary artery disease (heart disease caused by poor blood flow in the blood vessels of the heart), peripheral vascular disease (poor circulation in the hands or feet), or stroke.
Tryzan may also be used to reduce the risk of cardiovascular problems and complications in patients with diabetes aged 55 years or more who may be considered at risk because of one or more additional factors such as high blood pressure, high cholesterol levels, kidney problems, a current smoker, or previous disease of the blood vessels.
Tryzan works by widening the blood vessels, which reduces the pressure in the vessels, making it easier for your heart to pump blood around your body. This helps increase the supply of oxygen to your heart, so that when you place extra demands on your heart, such as during exercise, your heart may cope better and you may not get short of breath as easily.
By increasing the supply of oxygen to your heart, your heart does not have to work as hard and it is under less stress, which may reduce the risk of further damage occurring to it following a heart attack.
Tryzan also improves blood flow through the small blood vessels found in the kidneys, which helps the kidneys to work more efficiently. This in turn can help to slow down the progression of kidney damage that might result from having diabetes or high blood pressure.
Therefore, there are quite a few reasons why your doctor might have decided to treat you with Tryzan.
Your doctor may have also prescribed this medicine for another reason.
Tryzan is not recommended for use in children. Safety and effectiveness in children have not been established.
This medicine is available only with a doctor's prescription.
This medicine is not addictive.
Do not take Tryzan if you have had an allergic reaction to:
Some of the symptoms of an allergic reaction may include skin rash, itching or hives, swelling of the face, lips, mouth, throat or other parts of the body, shortness of breath, wheezing or troubled breathing.
Do not take Tryzan if you have ever taken any other ACE inhibitor medicine, which caused your face, lips, tongue, throat, hands or feet to swell up, or made it hard for you to breathe. If you have had an allergic reaction to an ACE inhibitor before, you could be allergic to Tryzan.
Do not take Tryzan if you or your family have a history of swelling of the face, lips, tongue, throat, intestines, hands or feet, for no apparent reason.
Do not take Tryzan if you have or have had any of the following medical conditions:
Do not take this medicine if you undergo dialysis using certain high-flux membranes.
Do not take this medicine if you are a diabetic or have kidney problems and are being treated with aliskiren-containing medications or a group of medicines known as AIIRAs (a medicine also used to treat high blood pressure).
Do not take this medicine if you are pregnant or plan to become pregnant. It may affect your developing baby if you take it during pregnancy.
Tell your doctor if you are breastfeeding or wish to breastfeed. Tryzan may pass into breast milk and affect your baby.
Check with your doctor or pharmacist if you are not sure about any of the above.
Do not take Tryzan after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal.
Tell your doctor if you are allergic to any other medicines, foods, dyes or preservatives.
Tell your doctor if you have a family history of swelling of the face, lips, tongue, throat, intestines, hands or feet.
Tell your doctor if you are following a very low or high salt diet.
Tell your doctor if you are dehydrated, or have had a recent bout of vomiting or diarrhoea.
Tell your doctor if you plan to become pregnant or wish to breastfeed.
Tell your doctor if you plan to have surgery or about to have general anaesthetic.
Tell your doctor if you have or have had any of the following medical conditions:
You must also tell your doctor if you:
If you have not told your doctor about any of the above, tell him/her before you start taking Tryzan.
Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop.
Some medicines may be affected by Tryzan or may affect how well it works. These include:
If you are taking Tryzan for high blood pressure, do not take any medicines (including the ones bought without a prescription) for appetite control, asthma, colds, coughs, hayfever or sinus problems unless you have discussed it with your doctor or pharmacist.
Your doctor can tell you what to do if you are taking any of these medicines.
If you are not sure whether you are taking any of these medicines, check with your doctor or pharmacist. Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking Tryzan.
Follow all directions given to you by your doctor and pharmacist carefully. They may differ from the information contained in this leaflet.
If you do not understand the instructions on the pack, ask your doctor or pharmacist.
The dose varies from person to person.
Your doctor will tell you how much Tryzan you need to take each day.
Ask your doctor or pharmacist for help if you do not understand the instructions on the label. Tryzan is usually started at a low dose and then increased slowly.
Your doctor will select a dose when they prescribe Tryzan for you. Some patients may need a lower starting dose. The usual dose of Tryzan is:
Your doctor may adjust the dose depending on your condition and the way you respond to Tryzan.
Tryzan should be swallowed whole with a glass of water.
Take your medicine at about the same time each day. Taking it at the same time each day will have the best effect. It will also help you remember when to take it.
It does not matter if you take your medicine before or after meals.
If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.
Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally.
Do not take a double dose to make up for the dose you missed. This may increase the chance of you getting an unwanted side effect.
If you miss more than one dose, or are not sure what to do, ask your doctor or pharmacist.
Keep taking Tryzan for as long as your doctor recommends. Tryzan helps control your condition, but does not cure it. Therefore Tryzan must be taken every day for as long as your doctor recommends.
Immediately telephone your doctor or the Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency at the nearest hospital, if you think you or anyone else may have taken too much Tryzan. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
If you take too much Tryzan, you may feel very dizzy, light-headed, or faint. You may also experience slow heartbeat.
Tell all the doctors, dentists and pharmacists who are treating you that you are taking Tryzan.
If you are about to be started on any new medicine, tell your doctor and pharmacist that you are taking Tryzan.
Make sure you drink enough water during exercise and hot weather when you are taking Tryzan, especially if you sweat a lot. If you do not drink enough water while taking Tryzan, you may feel faint, light-headed or sick. This is because your blood pressure is dropping suddenly. If you continue to feel unwell, tell your doctor.
If you have excess vomiting or diarrhoea while taking Tryzan, tell your doctor. You may lose too much water and salt and your blood pressure may drop too much.
If you feel light-headed or dizzy after taking your first dose of Tryzan, or when your dose is increased, tell your doctor immediately.
If you plan to have surgery that needs a general anaesthetic, tell your doctor or dentist that you are taking Tryzan. Your blood pressure may drop suddenly.
If you become pregnant or intend to become pregnant while taking Tryzan, tell your doctor immediately.
If you are about to have any blood tests, tell your doctor that you are taking Tryzan. Tryzan may interfere with the results of some tests.
Have your blood pressure checked when your doctor says, to make sure Tryzan is working.
Go to your doctor regularly for a check-up. Your doctor may occasionally do a blood test to check your potassium levels and see how your kidneys are working.
Do not give Tryzan to anyone else, even if they have the same condition as you.
Do not take Tryzan to treat any other complaints unless your doctor or pharmacist tells you to.
Do not stop taking Tryzan, or lower or increase the dosage, without checking with your doctor.
If you feel light-headed, dizzy or faint when getting out of bed or standing up, get up slowly. Standing up slowly, especially when you get up from bed or chairs, will help your body get used to the change in position and blood pressure. If this problem continues or gets worse, talk to your doctor.
Be careful driving or operating machinery until you know how Tryzan affects you. As with other ACE inhibitor medicines, Tryzan may cause dizziness, light-headedness, tiredness or drowsiness in some people. Make sure you know how you react to Tryzan before you drive a car, operate machinery, or do anything else that could be dangerous if you are dizzy or light-headed. If this occurs do not drive. If you drink alcohol, dizziness or light-headedness may be worse.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Tryzan. This medicine helps most people, but it may have unwanted side effects in some people. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Do not be alarmed by this list of possible side effects. You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following and they worry you:
These side effects are usually mild.
Tell your doctor as soon as possible if you notice any of the following:
These may be serious side effects. You may need medical attention. Serious side effects are rare.
If any of the following happen, tell your doctor immediately or go to Accident and Emergency at your nearest hospital:
These are very serious side effects.
You may need urgent medical attention or hospitalisation. These side effects are very rare.
Other side effects not listed above may also occur in some people.
Tell your doctor if you notice anything that is making you feel unwell.
Keep Tryzan where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
Keep your medicine in the pack until it is time to take them. If you take the medicine out of the pack they will not keep well.
Keep Tryzan in a cool dry place where the temperature stays below 25°C.
Do not store Tryzan or any other medicine in the bathroom or near a sink. Do not leave it in the car or on a window sill. Heat and dampness can destroy some medicines.
If your doctor tells you to stop taking Tryzan, or your medicine has passed its expiry date, ask your pharmacist what to do with any medicine that is left over.
Tryzan Caps come in four strengths of capsules:
Each pack contains 30 capsules.
Tryzan Tabs come in four strengths of tablets:
Each pack contains 30 tablets.
The capsules also contain the following inactive ingredients:
Tryzan Caps are gluten free.
The tablets also contain the following inactive ingredients:
Tryzan Tabs do not contain gluten.
Tryzan is supplied by:
Alphapharm Pty Limited
(ABN 002 359 739)
Level 1 30 The Bond
30-34 Hickson Road
Millers Point NSW 2000
Phone: (02) 9298 3999
Australian registration numbers:
This leaflet was prepared on
11 April 2014.
Tryzan Caps & Tryzan Tabs_cmi/Apr14/00
Published by MIMS/myDr June 2014