CODIS® Tablets

Aspirin 500 mg and codeine phosphate 8 mg

Consumer Medicine Information

What is in this leaflet

This leaflet answers some common questions about CODIS. It does not contain all the available information.

It does not take the place of talking to your doctor or pharmacist.

All medicines have benefits and risks.

If you have any concerns about taking CODIS, ask your doctor or pharmacist.

Keep this leaflet with the medicine. You may want to read it again.

What CODIS is used for

CODIS is used to provide short term relief of:

  • strong pain
  • headaches and migraine headaches
  • rheumatic and arthritic pain (body or joint pains)
  • fibrositis (muscle pain and stiffness )
  • muscular pain, strains and sprains
  • neuralgia (nerve pain)
  • toothaches
  • cold and flu symptoms
  • sore throats
  • period pain

CODIS also reduces fever.

If your symptoms persist or worsen, or new symptoms develop, talk to your doctor or pharmacist.

CODIS contains the active ingredients aspirin and codeine phosphate.

Aspirin belongs to a family of medicines called Non-Steroidal Anti-inflammatory Drugs (NSAIDs). These medicines work by relieving pain and inflammation.

Codeine phosphate belongs to a family of medicines called opioids and is used to relieve strong pain.

After taking codeine, the body changes codeine into the active morphine by a special liver enzyme. However, about 8% of people may experience less pain relief compared to others, as their bodies do not change codeine to morphine as well as others.

Although CODIS can relieve the symptoms of pain, inflammation and fever, it will not cure your condition.

Your doctor or pharmacist may have recommended CODIS for another reason. Ask your doctor or pharmacist if you have any questions about why CODIS has been recommended for you.

Before you take CODIS

When you must not take it

Do not take CODIS if:

  1. you have an allergy to:
  • CODIS or any of the ingredients listed at the end of this leaflet
  • Aspirin or any other NSAID medicine.
  • Codeine or any other opioid medicine.
Many medicines used to treat headaches or general pain contain aspirin (or other NSAID medicines), or codeine (or other opioid medicines). If you are not sure if you are taking any of these medicines, ask your pharmacist.
Symptoms of an allergic reaction to these medicines may include:
  • asthma, wheezing or shortness of breath
  • swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing
  • hives, itching or skin rash
  • fainting
If you are allergic to aspirin or NSAID medicines and take CODIS, these symptoms may be severe.
  1. you have asthma that is sensitive to aspirin or NSAIDs
  2. you have acute breathing difficulties such as bronchitis, unstable asthma or emphysema
  3. you are in the last three months of pregnancy
  4. you have a peptic ulcer (ie stomach or duodenal ulcer)
  5. you have erosive gastritis (problem with the lining of the stomach)
  6. you have recently vomited blood or material that looks like coffee grounds
  7. you have recent bleeding from the back passage (rectum), black sticky bowel motions or bloody diarrhoea
  8. you have diarrhoea caused by antibiotics or poisoning
  9. you have chronic constipation
  10. you have haemophilia (bleeding problem)
  11. you regularly drink large quantities of alcohol
  12. you have severe liver disease
  13. you have uraemia (a kidney related problem) or other kidney disease
  14. you are also using other medicines to thin your blood

Do not take CODIS if the packaging is torn or shows signs of tampering.

Do not take CODIS if the expiry date (EXP) printed on the pack has passed.

If you take this medicine after the expiry date has passed, it may not work.

If you are not sure whether you should start taking CODIS, contact your doctor.

Use in Children

CODIS is not recommended for use in children.

Do not give CODIS to a child under 12 years except on doctor's advice.

Do not give CODIS to children 12 to 16 years of age with or recovering from chicken pox, influenza or fever except on doctor's advice.

Before you start to take it

Tell your doctor or pharmacist if:

  1. you have any allergies to:
  • any other medicines
  • any other substances, such as foods, preservatives or dyes
  1. you are pregnant or intend to become pregnant.
If there is a need to consider CODIS during your pregnancy, you must discuss the risk and benefits with your doctor before using it.
Aspirin should not be used at all in the last 3 months of pregnancy.
  1. you are breast-feeding or plan to breast-feed.
CODIS passes into breastmilk and may affect your baby. If there is a need to consider CODIS whilst you are breastfeeding, you must discuss the risk and benefits with your doctor before using it.
  1. you have or have had any medical conditions, especially the following:
  • stomach ulcer or other stomach problems, including vomiting blood or bloody diarrhoea or recent surgery on the stomach or intestines
  • a tendency to bleed or other blood problems
  • asthma, wheezing, chronic cough, or other breathing conditions
CODIS can cause gastrointestinal (gut) bleeding.
CODIS can cause breathing difficulties and cause asthmatic attacks in some people.
  1. you plan to have surgery.
  2. yyou have a head injuryou have a history of drug or alcohol dependence
  3. you have a head injury
  4. you have an enlarged prostate
  5. if you have low blood pressure
  6. if you have an underactive thyroid

If you have not told your doctor or pharmacist about any of the above, tell them before you take any CODIS.

Talk to your doctor or pharmacist about taking this medicine if you are over 65 years of age. Taking this medicine may increase the risk of stomach, heart or kidney problems.

Taking other medicines

Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines may interfere with CODIS. These include:

  • anticoagulants (medicines used to thin your blood or to prevent blood clots)
  • medicines that help reduce the amount of uric acid in your body (eg probenecid, a medicine often used to treat gout)
  • certain medicines used to treat diabetes
  • certain diuretics - "water" or "fluid" medicines (medicines used to help you pass more urine, and to help treat high blood pressure)
  • urinary alkalisers (medicines that affect the acidity of your urine)
  • diphenylhydantoin and sodium valproate (medicines used to treat fits or epilepsy)
  • certain antibiotics
  • methotrexate (a medicine used to treat arthritis and some cancers)
  • barbiturates, sedatives or any other medicines used to help you relax or sleep, or to treat anxiety
  • medicines used to relieve stomach cramps/spasms
  • medicines to prevent travel sickness
  • medicines to treat Parkinson's disease
  • medicines for diarrhoea
  • metoclopramide (a medicine used for nausea and vomiting)
  • quinidine (a medicine used to treat abnormal or irregular heartbeat
  • phenothiazines and antipsychotic medicines (used to treat mental disorders)
  • monoamine oxidase inhibitors (medicines used to treat depression) if taken within the last 14 days

These medicines may be affected by CODIS, or may affect how well it works. You may need to take different amounts of your medicine, or you may need to take different medicines. Your doctor will advise you.

CODIS should not be taken at the same time as alcohol and caffeine.

Alcohol and caffeine may also affect the effects of CODIS.

How to take CODIS

How much to take

CODIS should be dissolved in water before swallowing.

Taking CODIS with or immediately after food may help minimise any stomach irritation.

The recommended dosage for adults is 1 to 2 tablets, dissolved in water. If necessary, repeat after 4 hours, but do not exceed 8 tablets in 24 hours, except on doctor's advice.

Follow all directions given to you by your doctor and pharmacist carefully.

They may differ from the information contained in this leaflet.

If you do not understand the instructions on the box, ask your doctor or pharmacist for help.

How long to take it

CODIS should be used for the temporary relief of symptoms and should be used strictly as directed by your doctor or pharmacist.

If your symptoms persist or worsen, or new symptoms develop, talk to your doctor or pharmacist.

Unless your doctor has told you to, do not take CODIS for more than a few days at a time.

Prolonged or excessive use without doctor's supervision could be harmful.

This medicine may be addictive if used for more than a few days at a time.

If you take too much (overdose)

Immediately telephone your doctor or Poisons Information Centre (telephone 13  11  26), or go to casualty at your nearest hospital, if you think that you or anyone else may have taken too much CODIS. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Keep these telephone numbers handy.

While you are using CODIS

Things you must do

If you become pregnant while taking CODIS tell your doctor immediately.

If you are about to start taking any new medicine tell your doctor and pharmacist that you are taking CODIS.

Tell all of the doctors, dentists, and pharmacists that are treating you that you are taking/using CODIS.

If you are going to have surgery, tell your doctor you are taking CODIS.

Things you must not do

Do not give CODIS to anyone else, even if they have the same condition as you.

Do not take CODIS to treat any other complaints unless your doctor tells you to.

Things to be careful of

Be careful driving or operating machinery until you know how CODIS affects you.

CODIS may cause dizziness or light-headedness in some people. Make sure you know how you react to CODIS before you drive a car, operate machinery, or do anything else that could be dangerous if you are dizzy or light-headed. If this occurs, do not drive. If you drink alcohol, dizziness or light-headedness may be worse.

Side effects

Check with your doctor as soon as possible if you have any problems while taking CODIS, even if you do not think the problems are connected with the medicine or are not listed in this leaflet.

Like other medicines, CODIS can cause some side effects. If they occur, most are likely to be minor and temporary. However, some may be serious and need medical attention.

Ask your doctor or pharmacist to answer any questions you may have.

CODIS can cause difficulty in breathing and cause asthmatic attacks or hypersensitivity reactions in some people, especially people who suffer from asthma, or have a family history of asthma.

The aspirin in CODIS can cause minor (but sometimes major) gastrointestinal (gut) bleeding, especially if used at high doses for long periods of time.

If any of the following happen, stop taking CODIS and tell your doctor immediately or go to casualty at your nearest hospital:

  • vomiting blood or material that looks like coffee grounds
  • bleeding from the back passage, black sticky bowel motions (stools) or bloody diarrhoea
  • swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing
  • asthma, wheezing, shortness of breath
  • sudden or severe itching, skin rash, hives
  • fainting, seizures or fits
  • pain or tightness in the chest

These are very serious side effects. You may need urgent medical attention or hospitalisation. These side effects are rare.

Some reactions reported with aspirin or codeine use include:

  • Constipation
  • Nausea/vomiting
  • Dizziness/drowsiness
  • Tinnitus (buzzing or ringing in the ears)
  • Short term deafness
  • Vertigo (loss of balance)
  • Allergic skin reactions
  • Kidney and liver problems (especially at high doses)
  • Metabolic acidosis (acid imbalance in the blood)

Other side effects not listed above may also occur in some patients. Tell your doctor if you notice anything else that is making you feel unwell.

Ask your doctor or pharmacist if you don't understand anything in this list.

Do not be alarmed by this list of possible side effects. You may not experience any of them.

After using CODIS


Keep your tablets in the pack until it is time to take them. If you take the tablets out of the pack they will not keep well.

Keep the tablets in a cool dry place where the temperature stays below 30°C. Do not store CODIS or any other medicine in the bathroom or near a sink. Do not leave it in the car or on window sills. Heat and dampness can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.


If your doctor tells you to stop taking CODIS or the tablets have passed their expiry date, ask your pharmacist what to do with any that are left over.

Product description

What it looks like

CODIS Tablets are white, circular, flat tablet with bevelled edges and embossed with 'C-sword' motif on one side; plain on the other side and are available in blister packs of 48 (and 24) tablets.


Each tablet contains 500 milligrams of aspirin and 8 milligrams of codeine phosphate as the active ingredients. The other ingredients in the tablet are maize starch, calcium carbonate, purified talc, saccharin, sodium lauryl sulfate and anhydrous citric acid.

Each pack of CODIS Tablets is marked with Australian Registration Number: AUST R 15358


Reckitt Benckiser
44 Wharf Road
West Ryde NSW 2114

Date of Preparation of Leaflet:
02 February 2010

© Reckitt Benckiser 2010

Published by MIMS August 2010

Consumers should be aware that the information provided by the Consumer Medicines Information (CMI) search (CMI Search) is for information purposes only and consumers should continue to obtain professional advice from a qualified healthcare professional regarding any condition for which they have searched for CMI. CMIs are provided by MIMS Australia. CMI is supplied by the relevant pharmaceutical company for each consumer medical product. All copyright and responsibility for CMI is that of the relevant pharmaceutical company. MIMS Australia uses its best endeavours to ensure that at the time of publishing, as indicated on the publishing date for each resource (e.g. Published by MIMS/myDr January 2007), the CMI provided was complete to the best of MIMS Australia's knowledge. The CMI and the CMI Search are not intended to be used by consumers to diagnose, treat, cure or prevent any disease or for any therapeutic purpose. Dr Me Pty Limited, its servants and agents shall not be responsible for the continued currency of the CMI, or for any errors, omissions or inaccuracies in the CMI and/or the CMI Search whether arising from negligence or otherwise or from any other consequence arising there from.