Metoclopramide hydrochloride/Paracetamol

Consumer Medicine Information

What is in this leaflet

This leaflet answers some common questions about Anagraine. It does not contain all the available information. It does not take the place of talking to your pharmacist or doctor.

All medicines have risks and benefits.

If you have any concerns about taking this medicine, talk to your doctor or pharmacist.

Keep this leaflet with the medicine. You may need to read it again.

What Anagraine is used for

Anagraine is used for the relief of headache, nausea and vomiting associated with migraine.

Anagraine contains the active ingredients metoclopramide and paracetamol.

Metoclopramide helps control nausea and vomiting caused by migraine and other illnesses. It works by blocking the action of a chemical in the brain which causes nausea and vomiting. Metoclopramide also acts in the stomach and upper intestine to increase muscle contractions.

Paracetamol is an analgesic. It provides effective temporary relief from pain.

This medicine is not addictive.

Before you take Anagraine

When you must not take it

Do not take Anagraine if:

  • you are allergic to metoclopramide or paracetamol or to any of the ingredients listed at the end of this leaflet.
Signs of an allergic reaction may include asthma, wheezing, shortness of breath, swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing, skin rash, itching or hives.
  • you have any of the following conditions:
- bleeding from the stomach and/or digestive tract
- intestinal blockage
- recent surgery on the stomach and/or digestive tract
- phaeochromocytoma (a rare tumour of the adrenal gland)
  • the expiry date (EXP) printed on the pack has passed
  • the packaging is torn or shows signs of tampering, or if the tablets do not look quite right

If you are not sure whether you should start taking Anagraine talk to your doctor or pharmacist.

Do not give Anagraine to children under 12 years of age.

Before you start to take it

Tell your doctor or pharmacist if:

  1. you have allergies to any other medicines, foods, preservatives or dyes.
  2. you have or have had any of the following medical conditions:
  • epilepsy - metoclopramide may increase the risk of you having a fit
  • Parkinson's disease - metoclopramide may make this condition worse
  1. you are pregnant or plan to become pregnant. Your doctor or pharmacist will discuss with you the possible risks and benefits of using Anagraine during pregnancy.
  2. you are breast-feeding or plan to breastfeed.
Anagraine passes into breast milk and although the effect on your baby is not known, there is a possibility that your breastfed baby may be affected.

If you have not told your doctor or pharmacist about any of the above, tell them before you use Anagraine.

Taking other medicines

Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop. These medicines may be affected by Anagraine or may affect how well it works. You may need to take different amounts of your medicines, or you may need to take different medicines. Your doctor or pharmacist will advise you.

Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking Anagraine.

How to take Anagraine

How much to take

The initial dosage for adults is 1-2 tablets. The initial dosage for adolescents 12 to 17 years old is 1 tablet. Anagraine should be taken at the first sign of a migraine attack.

If symptoms persist, repeat every four hours. For adults: Do not take more than 6 tablets in 24 hours. For adolescents aged 12 to 17 years, do not exceed 3 tablets in 24 hours.

How to take it

Swallow the tablets with a glass of water.

If you forget to take it

If symptoms persist take your next dose when you are meant to.

Do not take a double dose to make up for the dose that you missed. This may increase the chance of you getting an unwanted side effect.

If you are not sure what to do, ask your doctor or pharmacist.

If you have trouble remembering when to take your medicine, ask your pharmacist for some hints.

If you take too much (overdose)

Immediately telephone your doctor or the Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency at the nearest hospital, if you think that you or anyone else may have taken too much Anagraine. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.

If you take too much Anagraine you may have:

  • vomiting
  • sweating
  • low blood pressure
  • yellowing of the skin
  • drowsiness
  • confusion
  • twitching or uncontrolled spasms

While you are taking Anagraine

Things you must do

Tell your doctor or pharmacist if nausea, vomiting or headache persists.

Tell all doctors, dentists and pharmacists who are treating you that you are taking Anagraine.

If you are about to be started on any new medicine, tell your doctor or pharmacist that you are taking Anagraine.

Things you must not do

Do not take Anagraine to treat any other complaints unless your doctor or pharmacist tells you to.

Things to be careful of

Be careful taking other medications containing paracetamol. Not more than 4 g of paracetamol should be taken in any 24 hour period. Speak to your doctor or pharmacist before using Anagraine with any other medicine containing paracetamol.

Be careful driving or operating machinery until you know how Anagraine affects you.

Side effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Anagraine. Anagraine helps most people with nausea and pain but may have some unwanted effects in some people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor or pharmacist if you notice any of the following and they worry you:

- drowsiness, tiredness, dizziness restlessness, fatigue
- bowel upsets
- upset stomach
- allergic reactions

These are the more common side effects of your medicine.

Other side effects not listed above may also occur in some people. Tell your doctor or pharmacist if you notice anything that is making you feel unwell.

After using Anagraine


Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister they may not keep well.

Keep your tablets in a cool dry place where the temperature stays below 30°C.

Do not store Anagraine or any other medicine in the bathroom or near a sink. Do not leave it on a window sill or in the car. Heat and dampness can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.


If you stop taking this medicine or the expiry date has passed, ask your pharmacist what to do with any medicine that is left over.

Product description

What it looks like

Anagraine tablets are round, white and scored. They are available in packs of 8 tablets.


Each Anagraine tablet contains 5 mg of metoclopramide hydrochloride and 500 mg of paracetamol as the active ingredients.

It also contains:

  • magnesium stearate
  • sodium starch glycollate


Anagraine is supplied in Australia by:

Aspen Pharmacare Australia Pty Limited
34-36 Chandos St
St Leonards NSW 2065

Australian Registration Number

AUST R 13547.

Date of preparation: March 2005

Last updated: August 2006

Published by MIMS November 2006

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